Burning fat is the achilles heel of β-catenin mutated HCC [wz7g1NabgGr]

Burning fat is the achilles heel of β-catenin mutated HCC [wz7g1NabgGr]

| 1h 28m 28s | Video has closed captioning.

To cite: Senni N, Savall M, Cabrerizo Granados D, et al. Gut 2019;68:322-334. Read the full article here: Objectives: CTNNB1-mutated hepatocellular carcinomas (HCCs) constitute a major part of human HCC and are largely inaccessible to target therapy. Yet, little is known about the metabolic reprogramming induced by β-catenin oncogenic activation in the liver. We aimed to decipher such reprogramming and assess whether it may represent a new avenue for targeted therapy of CTNNB1-mutated HCC. Conclusions: FAO induced by β-catenin oncogenic activation in the liver is the driving force of the β-catenin-induced HCC. Inhibiting FAO by genetic and pharmacological approaches blocks HCC development, showing that inhibition of FAO is a suitable therapeutic approach for CTNNB1-mutated HCC. #is there a keto pill #keto science keto burn pills #keto nlast gummies